This essay interrogates the relations between mind and matter through the lens of children’s unexplained experiences and medical conditions. Conditions that can affect regions of the body through inflammation, such as epilepsy, PANS/PANDAS and narcolepsy, are examined against reports of increased extra sensory experiencing in children. Epigenetics is used as an example to show how ancestors, in the form of great grandparents, may be the true progenitors of children’s psychic contents, fused within a participation mystique (Jung).